Peptid radioligandlari

Peptid radioligandlari

Chelators like DTPA, DOTA, DOPA, NOTA, NODAGA, and HYNIC are often attached to the N-terminus of peptides, but can also be linked to the internal or C-terminus via an inserted lysine. These chelator-peptide complexes form stable associations with metal ions, facilitating their attachment for therapeutic or diagnostic applications.

Dietilentriaminpentaasetik kislota (DTPA) yadro tibbiyotida tasvirlash uchun qo'llaniladigan (68) Ga, (99 m) Tc va (111) In kabi radionuklidlar uchun foydali xelatlashtiruvchi vositadir.

DOTA

DOTA (1,4,7,10-tetraazatsiklododekan-1,4,7,10-tetraasetik kislota)-peptid konjugatlarining metall komplekslari maqsadli tasvirlash va terapevtik radiofarmatsevtika va MRI kontrast agentlari sifatida tobora ko'proq foydalanilmoqda.

Boshqa radioligandlar